Dr. Daniel A. Erlanson is the co-founder and VP of Chemistry for Carmot Therapeutics, Inc. Using a proprietary technology called Chemotype Evolution, Carmot is addressing unmet chemical needs in drug discovery to tackle challenging therapeutic targets. Prior to Carmot, Dr. Erlanson spent a decade developing fragment-based drug discovery technologies and leading medicinal chemistry efforts in oncology and in metabolic and inflammatory diseases at Sunesis Pharmaceuticals, which he joined at the company’s inception. Before Sunesis, he was an NIH postdoctoral fellow with James A. Wells at Genentech. Dr. Erlanson earned his PhD in chemistry from Harvard University in the laboratory of Gregory L. Verdine and his BA in chemistry from Carleton College. As well as co-editing two books on fragment-based drug discovery, Dr. Erlanson is an inventor on more than a dozen issued patents and an author of more than forty scientific publications. He is also editor of a blog devoted to fragment-based drug discovery, Practical Fragments.
Dr. Alba T. Macias is a Principal Scientist and project leader working in fragment-based drug discovery at Vernalis Ltd, a Ligand company. Vernalis combines fragment based approaches, structural biology, biophysics, assay technology, molecular modelling and medicinal chemistry in its drug discovery platform. Dr. Macias is a computational chemist with a particular interest in protein modelling, selectivity and design of covalent inhibitors. These approaches are used for detailed structure-based optimisation of fragments and lead compounds, as well as the design of compound libraries for off-rate-screening using surface plasmon resonance. Off-rate screening allows for rapid elaboration of fragments into leads. Since joining Vernalis in 2006, her contributions to internal projects and collaborations with external partners have resulted in numerous patents, publications, and clinical candidates. After completing a double-major in Chemistry and Mathematics, Dr. Macias pursued a PhD in chemistry under the supervision of Professor Jeffrey D. Evanseck at the University of Miami (USA). She then became an NIH postdoctoral fellow at the School of Pharmacy, University of Maryland at Baltimore, where she trained with Professor Alexander D. MacKerell.
Iwan de Esch
Prof. Iwan de Esch is professor at the Medicinal Chemistry division of VU University Amsterdam. His rsearch aims to understand and predict interactions between biologically active ligands and their molecular targets. The group makes extensive use of Computer-Aided Drug Design (CADD) and organic chemistry to design and synthesize new ligands. Hit finding and optimization efforts are guided by Fragment-Based Drug Design (FBDD) approaches. Various protein classes are being interrogated, including, GPCRs, PDEs, AChBP and LGICs, protein-protein interactions, kinases and others. Next to hit finding, the group has experience in hit and lead optimization, leading amongst others to clinical candidates for the histamine H4 receptor. In 2011, he received the Galenus Research Price for his work on Fragment-Based Drug Discovery and valorization activities. He is co-founder of three academic spin-out companies, i.e., De Novo Pharmaceuticals Ltd (a spin-out from the University of Cambridge, UK), IOTA Pharmaceuticals Ltd and Griffin Discoveries BV (spin-outs of VU University Amsterdam). Iwan de Esch is coordinator of FRAGNET, a European training network that focusses on developing FBDD.
Dr. Reto Horst
Dr. Reto Horst is a Principal Scientist in the Structural and Molecular Sciences group at Pfizer in Groton, CT, USA. He is developing and applying cutting edge NMR methods to identify and validate hits from various screening funnels and to characterize protein–ligand interactions. Dr. Horst has guided fragment-based drug discovery efforts in various disease areas and made key contributions to several discovery projects. Dr. Horst obtained a diploma (MSc) in Physics and a PhD in Biophysics under the supervision of Nobel Laureate Dr. Kurt Wuthrich at the ETH in Zurich, Switzerland. Before joining Pfizer in 2012, he was a Staff Scientist at Scripps Research in La Jolla, CA, where his research was focused on studying GPCR signaling pathways and chaperonin-assisted protein folding by solution state NMR spectroscopy, resulting in 25 peer-reviewed publications that appeared in Tier 1 journals including Cell, Science and PNAS.